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. 2009 Jun 3;106(24):9848–9853. doi: 10.1073/pnas.0901840106

Fig. 3.

Fig. 3.

Environmental enrichment increases brain EpoR and Epo gene expression. (A) Level of EpoR transcript was measured in the NC, the HiD, the HiV, and the VLR of rats raised in SC or EC, and subjected or not to 3H. In 3H groups, tissues were collected at reoxygenation time of the last hypoxic exposure (*, P < 0.001, compared with SC; †, P < 0.001, compared with EC). (B) Three days after reoxygenation time in rats housed in EC and subjected to 3H, the number of cells in which EpoR was detected increased, compared with rats raised in SC. (C) Constitutive expression of Epo was increased in the HiD, the HiV, and the VLR in rats raised in EC compared with SC (*, P < 0.05). (D) Brain reactivity of Epo gene expression to 3H, measured at transcript level, was not affected by housing conditions. All bars represent mean ± SEM (n = 4 in each group).