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. 2009 May 29;106(24):9607–9612. doi: 10.1073/pnas.0902420106

Fig. 4.

Fig. 4.

Induction of CAG repeat instability induced by ZFNs. The ZFNs were evaluated in (A) CHO cells and (B) human cells. The frequencies represent the averages of at least 6 independent experiments, with the exception of the zfGCA+GFP treatments for which there were at least 3 independent experiments. The standard deviations are indicated by the vertical bars. The values (×10−6) for each condition in CHO APRT(CAG)95 cells are: GFP (8.9 ± 2.6), zfGCT+GFP (90 ± 23), zfGCA+GFP (5.0 ± 1.6), and zfGCA+zfGCT (130 ± 31). For CHO APRT(CAG)61 cells, the values are: GFP (15 ± 5.7) and zfGCT+GFP (39 ± 6.6). For the human HPRT(CAG)95 cells, the value were: GFP (8.0 ± 4.5), zfGCT+GFP (55 ± 23), and zfGCA+GFP (4.6 ± 3.3). For the human HPRT(CAG)68 cells, the value are: GFP (8.0 ± 4.1) and zfGCT+GFP (17 ± 7.7).