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. 2008 Aug 27;3:103–109. doi: 10.4137/aci.s953

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Copyright © 2008 The authors.

This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0.

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Figure 2. — Representative HPLC Chromatograms for (A) a standard buffer solution spiked with griseofulvin (500 ng/mL) and the IS (warfarin; 50 μg/mL); (B) blank rat plasma; (C) blank rat plasma spiked with griseofulvin (500 ng/mL) and the IS (50 μg/mL); (D) rat plasma sample obtained 5 hr after a 50 mg/kg oral dose of griseofulvin; (E) Limit of detection (LOD) of griseofulvin in rat plasma: 1 ng/mL; and (F) Limit of quantification (LOQ) of griseofulvin in rat plasma: 10 ng/mL. Peak 1 = griseofulvin and Peak 2 = IS.

Figure 2. — Representative HPLC Chromatograms for (A) a standard buffer solution spiked with griseofulvin (500 ng/mL) and the IS (warfarin; 50 μg/mL); (B) blank rat plasma; (C) blank rat plasma spiked with griseofulvin (500 ng/mL) and the IS (50 μg/mL); (D) rat plasma sample obtained 5 hr after a 50 mg/kg oral dose of griseofulvin; (E) Limit of detection (LOD) of griseofulvin in rat plasma: 1 ng/mL; and (F) Limit of quantification (LOQ) of griseofulvin in rat plasma: 10 ng/mL. Peak 1 = griseofulvin and Peak 2 = IS.