Table 1.
| ||||
---|---|---|---|---|
entry | oxime | R | yield (%)a,b | ee (%)c |
1 | a | Me | 85 | 95 |
2 | b | Bn | 77 | 97 |
3 | c | 4-MeOBn | 70 | 97 |
4 | d | 4-CF3Bn | 60 | 99 |
5 | e | 2-NO2Bn | 95 | 97 |
Borane was stabilized with <0.005 M N-isopropyl N-methyl tert-butylamine.
Isolated yield after purification by column chromatography.
The ee was analyzed using a Crompack Chirasil-Dex-CB GC column.