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. Author manuscript; available in PMC: 2009 Jun 23.
Published in final edited form as: Psychoneuroendocrinology. 2007 Nov 26;33(1):108–117. doi: 10.1016/j.psyneuen.2007.10.007

Figure 3.

Figure 3

Social stress caused functional glucocorticoid resistance in wildtype (WT) but not in IL-1 receptor type 1-deficient (IL-1R1−/−) mice. Ex vivo glucocorticoid sensitivity of splenocytes from control mice and from mice that were subjected to six cycles of social disruption (SDR). Twelve hours after the last stress cycle, splenocytes were isolated and cultured with LPS (1 µg/ml) in the presence of various concentrations of CORT. Data are presented as percentage of cell viability in the absence of CORT. Repeated measure ANOVA; *p<0.05 vs. all other groups; n = 6 per group.