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Pharmacologic Properties of the SSRIs: Their Effect on the Uptake of Biogenic Amines in Vitro (Adapted from: Hyttel J, 1994; Burke WJ & Kratochvil CJ, 2002) [160, 167]
| SSRI | Monoamine Uptake Inhibition, IC50 value (nM) | IC50 NA Uptake / IC50 5-HT Uptake | ||
|---|---|---|---|---|
| Serotonin | Noradrenaline | Dopamine | ||
| Fluoxetine | 6.8 | 370 | 5000 | 54 |
| Sertraline | 0.19 | 160 | 48 | 840 |
| Paroxetine | 0.29 | 81 | 5100 | 280 |
| Fluvoxamine | 3.8 | 620 | 42000 | 160 |
| Citalopram | 1.8 | 6100 | 40000 | 3400 |
| Escitalopram | 1.5 | 2500 | 65000 | 1700 |
