Table 7.

Summary of the Involvement of σ₁ Receptors in the Behavioral Effects Induced by Cocaine (see References and Text for Detailed Information)

Involvement of σ1 Receptors in Cocaine-Induced Behavioral Effects
			Behavioral Experimental Model	Effect of σ1 Agonists	Effect of σ1 Antagonism
Acute effects of cocaine	Psychostimulant effects		Locomotor activity [37, 95, 111, 109, 112, 124]	Potentiation	Inhibition
	Toxicity		Convulsions [37, 109, 111, 112, 113, 124]
			Lethality [37, 112, 113, 124]
Repeated administration of cocaine	Self-reported effects of cocaine		Drug discrimination test [83, 95, 221]	Not tested	Slight or no effect
	Nervous system plasticity		Locomotor sensitization [206, 221]	Not tested	Inhibition
	Rewarding properties	During addictive behavior	Conditioned place preference [168, 169]	Not tested	Inhibition
			Self-administration [101]	Not tested	No effect
		After extinction of addictive behavior	Conditioned place preference after priming injection of drugs [170]	Reactivation	Inhibition
			Discriminative stimulus associated with cocaine availability for self-administration [101]	Not tested	Inhibition