Table 2.

Carotid Artery Intima-Media Thickness (CIMT) Progression by Treatment Group

	B-Vitamins (n=248)	Placebo (n=242)	p-value*
All subjects, adjusted for baseline CIMT strata (<≥0.75 mm)	0.0022 (0.0005)†	0.0029 (0.0007)	0.31
Baseline fasting plasma total homocysteine
<9.1 μmol/L (n=126/119)‡	0.0028 (0.0006)	0.0021 (0.0007)	0.41
≥9.1 μmol/L (n=122/123)	0.0016 (0.0007)	0.0038 (0.0007)	0.02

^*p-values from mixed effects models

^†Mean (SE) carotid artery intima-media thickness (CIMT) progression rate (mm/year)

^‡Sample sizes in sub-group analysis (B-vitamins/Placebo)