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. Author manuscript; available in PMC: 2009 Jun 23.
Published in final edited form as: Autoimmunity. 2004;37(6-7):445–451. doi: 10.1080/08916930400008524

FIGURE 5.

FIGURE 5

Phenotypic analysis of spleen cells at 22 weeks. Flow cytometry data showing the percentage of cells mice (left panels) and the total number of cells (right panels) in the spleens of treated and control mice. Young female NZW/BXSB mice are used as a negative control. Results for mice treated at 9 weeks of age were similar in spleens harvested at 22 and 30 weeks and are pooled. Untreated mice had an increased number of CD19 + B cells and of CD11c+/CD11b+dendritic cells, an increased number of activated (CD69+) CD4+T and B cells and an increased number of memory (CD44+/CD62L-) CD4+T cells compared with young female NZW/BXSB. Mice treated with CTLA4Ig at 9 weeks had a similar phenotype as young females, whereas mice treated with CTLA4Ig at 12 weeks were intermediate between untreated and 9 week treated mice. (* indicates p < 0.03 treated vs. untreated age matched control. Only significant p values are shown).