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. Author manuscript; available in PMC: 2010 Apr 16.
Published in final edited form as: J Phys Chem B. 2009 Apr 16;113(15):5208–5216. doi: 10.1021/jp809000e

Figure 8.

Figure 8

(A) Values of dDNA for DOTAP/DOPC/steroid–DNA complexes obtained from X-ray diffraction data. There is no significant difference in dDNA for the different steroids, and the DNA spacing monotonically decreases from 63 Å to 27 Å for all studied molecules. However, dDNA of CL–DNA complexes containing cholesterol and ergosterol is always about 1–2 Å larger than dDNA of CL–DNA complexes containing β-estradiol, progesterone or dehydroisoandrosterone. (B) The lamellar spacing d of DOTAP/DOPC/steroid–DNA complexes obtained from X-ray diffraction data. The lamellar spacing is generally up to 5 Å higher for CL–DNA complexes containing cholesterol and ergosterol than for complexes containing the other steroids, suggesting different packing of these groups of molecules within the lipid bilayer.