. 2009 Apr 29;18(14):2683–2692. doi: 10.1093/hmg/ddp192

Table 1.

Published risk estimates of severe malaria phenotypes associated with CD36 deficiency alleles

Publication	Population	Cases	Controls	Phenotype	Allele/genotype	OR	95% CI	P-value
Aitman et al. (2000) (12)	Gambia and Kenya	598	761	All cases	def versus wt	1.53	1.09–2.15	0.01^a
		(388)^b	761	CM	def versus wt	1.49	1.01–2.20	0.04
		(97)	(331)	CM	GG versus rest	—	—	0.04
Pain et al. (2001) (17)	Kenya	693	693	All cases	GG and GT versus TT	0.74	0.55–0.99	0.036^a
		(104)	693	Three or four syndromes	GG and GT versus TT	0.47	0.22–0.95	0.024
		(589)	693	One or two syndromes	GG and GT versus TT	0.79	0.58–1.07	0.11
		(413)	693	CM	GG and GT versus TT	0.84	0.60–1.18	0.27
		(250)	693	Respiratory distress	GG and GT versus TT	0.67	0.43–1.04	0.051
		(304)	693	SA	GG and GT versus TT	0.62	0.41–0.94	0.017
		(146)	693	Hypoglycaemia	GG and GT versus TT	0.54	0.30–0.96	0.026
Amodu et al. (2005) (18)	Nigeria	101	53	Uncomplicated versus asymptomatic	G versus T	—	—	0.062^c
		69	53	Severe versus asymptomatic	G versus T	—	—	0.326
Ayodo et al. (2007) (19)	Luo (Kenya)	456	457	All cases	GT versus rest	1.5	1.03–2.18	0.03
		456	457	All cases	GG versus GT versus TT	—	—	0.061
		456	457	All cases	G versus T	—	—	0.0023^d
		456	457	All cases	G versus T	—	—	0.00043^e

OR, odds ratio; CI, confidence interval; def, CD36 deficiency alleles 1264G and 1439C pooled; wt, CD36 wild-type allele; the remaining alleles and genotypes refer to CD36 T1264G. CM, cerebral malaria; SA, severe anaemia; Severe, all severe cases; Uncomplicated, non-severe malaria.

^aMantel–Haenszel stratified analysis.

^bSample numbers in brackets refer to subsets of the studies’ cases or controls.

^cMultivariate analysis.

^dWeighted for population differentiation (Yoruba versus Masai).

^eWeighted for population differentiation (Yoruba versus Kikuyu).