Table 2.

Haplotype association analysis in female cases and female controls within DISC1 haplotype blocks 22 and 23

Haplotype block	Sample/sub-sample	Haplotype	% Patientsa	% Controlsa	P-value	Global P-value
Block 22
9-SNP-haplotypeb	Female	GTCGACTGG	0.411	0.311	0.00009	0.0184
		ACCAACGAG	0.162	0.210	0.01860
	Female EAO	GTCGACTGG	0.469	0.307	0.00008	0.0090
		ACCAACGAG	0.130	0.213	0.01586
Block 23
4-SNP-haplotypec	Female	GTAT	0.070	0.036	0.00372	0.0448
	Female EAO	GTAT	0.098	0.035	0.00074	0.0155
Block 22–23
13-SNP-haplotyped	Female	GTCGACTGGGTGT	0.325	0.252	0.00279	0.0265
		GTCGACTGGGTAT	0.066	0.033	0.00483
		ACCAACGAGGTGT	0.151	0.201	0.01428
	Female EAO	GTCGACTGGGTGT	0.365	0.254	0.00464	0.0072
		GTCGACTGGGTAT	0.089	0.033	0.00207
		ACCAACGAGGTGT	0.132	0.204	0.03770
Block 22–23
12-SNP-haplotypee	Female	GTCGACTGGGTT	0.388	0.284	0.00004	0.0367
		ACCAACGAGGTT	0.149	0.200	0.01146
	Female EAO	GTCGACTGGGTT	0.444	0.285	0.00009	0.0239
		ACCAACGAGGTT	0.129	0.204	0.02841

Only haplotypes with significant differences between cases and controls are presented and only P-values <0.05 are given in bold.

^aEstimated haplotype frequencies in patients and controls. Estimations are based on each analyzed sample (all female patients and all female controls, EAO female patients and all female controls).

^bSNP-marker combination rs1015101–rs999710–rs11122355–rs9431711–rs17820909–rs11122362–rs4658890–rs4333837–rs11122366.

^cSNP-marker combination rs11585831–rs967433–rs17770256–rs821723.

^dSNP-marker combination rs1015101–rs999710–rs11122355–rs9431711–rs17820909–rs11122362–rs4658890–rs4333837–rs11122366–rs11585831–rs967433–rs17770256–rs821723.

^eSNP-marker combination rs1015101–rs999710–rs11122355–rs9431711–rs17820909–rs11122362–rs4658890–rs4333837–rs11122366–rs11585831–rs967433–rs821723.