Table 3.
DISC meta-analysis in nine schizophrenia case–control samples from European populations
| SNP | Positiona | Inter-bp | Study and Sample | Cases | Controls | OR | z-value | P-value | P-value Heterogeneity |
|---|---|---|---|---|---|---|---|---|---|
| rs4658879 | 229809198 | Present Study | 782 | 839 | 1.21 | 2.087 | 0.037 | ||
| Wood et al. (11) | 311 | 291 | 1.00 | 0.000 | 1.000 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 1.06 | 0.428 | 0.668 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 1.05 | 0.353 | 0.724 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 1.22 | 1.256 | 0.209 | ||||
| Hennah et al. (7), London | 348 | 351 | 1.08 | 0.538 | 0.591 | ||||
| Meta-analysis | 2368 | 2393 | 1.12 | 2.126 | 0.033 | 0.848 | |||
| rs1572899 | 229892113 | 82915 | Present study | 782 | 839 | 1.08 | 0.858 | 0.391 | |
| Hennah et al. (7), Edinburgh | 328 | 315 | 1.17 | 1.117 | 0.264 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 1.00 | 0.022 | 0.982 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 1.35 | 1.856 | 0.063 | ||||
| Hennah et al. (7), London | 348 | 351 | 1.06 | 0.402 | 0.688 | ||||
| Hodgkinson et al. (10) | 196 | 217 | 1.46 | 2.127 | 0.033 | ||||
| Meta-analysis | 2253 | 2319 | 1.13 | 2.353 | 0.019 | 0.470 | |||
| rs2812385 | 229930625 | 38512 | Present study | 782 | 839 | 1.04 | 0.447 | 0.655 | |
| Wood et al. (11) | 311 | 291 | 1.04 | 0.256 | 0.798 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 1.14 | 0.889 | 0.374 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 1.17 | 1.141 | 0.254 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 1.46 | 2.343 | 0.019 | ||||
| Hennah et al. (7), London | 348 | 351 | 1.08 | 0.571 | 0.568 | ||||
| Meta-analysis | 2368 | 2393 | 1.12 | 2.097 | 0.036 | 0.582 | |||
| rs1538979 | 229963491 | 32866 | Present study | 782 | 839 | 1.14 | 1.421 | 0.155 | |
| Sullivan et al. (13) | 738 | 733 | 1.12 | 1.195 | 0.232 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 1.03 | 0.229 | 0.819 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 1.37 | 2.269 | 0.023 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 1.29 | 1.588 | 0.112 | ||||
| Hennah et al. (7), London | 348 | 351 | 1.06 | 0.398 | 0.691 | ||||
| Meta-analysis | 2795 | 2835 | 1.04 | 2.860 | 0.004 | 0.677 | |||
| rs16854957 | 229979516 | 16025 | Present study | 782 | 839 | 0.85 | 0.171 | 0.864 | |
| Wood et al. (11) | 311 | 291 | 0.79 | 0.330 | 0.741 | ||||
| Sullivan et al. (13) | 738 | 733 | 0.84 | 0.066 | 0.947 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 0.98 | 2.075 | 0.038 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 0.84 | 0.707 | 0.480 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 0.93 | 2.394 | 0.017 | ||||
| Hennah et al. (7), London | 348 | 351 | 0.96 | 1.677 | 0.093 | ||||
| Meta-analysis | 3106 | 3126 | 1.22 | 2.368 | 0.017 | 0.247 | |||
| rs17817356 | 229986844 | 7328 | Present study | 782 | 839 | 0.86 | 0.254 | 0.800 | |
| Sullivan et al. (13) | 738 | 733 | 0.93 | 1.137 | 0.256 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 0.77 | 0.166 | 0.868 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 0.98 | 2.137 | 0.033 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 0.82 | 3.157 | 0.002 | ||||
| Hennah et al. (7), London | 348 | 351 | 0.94 | 1.534 | 0.125 | ||||
| Meta-analysis | 2795 | 2835 | 1.27 | 3.007 | 0.002 | 0.100 | |||
| rs1322784 | 229995558 | 8714 | Present study | 782 | 839 | 0.92 | 1.012 | 0.311 | |
| Sanders et al. (12) | 1870 | 2002 | 0.93 | 0.714 | 0.475 | ||||
| Hennah et al. (7). - Edinburgh | 328 | 315 | 0.81 | 0.492 | 0.623 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 0.96 | 1.638 | 0.101 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 0.80 | 0.576 | 0.565 | ||||
| Hennah et al. (7), London | 348 | 351 | 0.91 | 1.260 | 0.208 | ||||
| Hodgkinson et al. (10) | 196 | 217 | 0.97 | 1.800 | 0.072 | ||||
| Meta-analysis | 4123 | 4321 | 1.19 | 2.430 | 0.015 | 0.716 | |||
| rs860275 | 230102768 | 107210 | Present study | 782 | 839 | 1.00 | 2.004 | 0.045 | |
| Wood et al. (11) | 311 | 291 | 0.79 | 0.331 | 0.741 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 0.85 | 0.840 | 0.401 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 0.93 | 1.438 | 0.151 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 0.93 | 1.519 | 0.129 | ||||
| Hennah et al. (7), London | 348 | 351 | 0.84 | 0.674 | 0.501 | ||||
| Meta-analysis | 2368 | 2393 | 1.29 | 2.896 | 0.004 | 0.938 | |||
| rs7541019 | 230117808 | 15040 | Present study | 782 | 839 | 0.93 | 1.208 | 0.227 | |
| Sullivan et al. (13) | 738 | 733 | 0.90 | 0.837 | 0.403 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 0.94 | 1.523 | 0.128 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 0.82 | 0.572 | 0.568 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 0.86 | 1.004 | 0.315 | ||||
| Hennah et al. (7), London | 348 | 351 | 0.81 | 0.383 | 0.702 | ||||
| Meta-analysis | 2795 | 2835 | 1.22 | 2.227 | 0.025 | 0.963 | |||
| rs2038636 | 230121872 | 4064 | Present study | 782 | 839 | 0.95 | 1.361 | 0.174 | |
| Wood et al. (11) | 311 | 291 | 0.87 | 0.997 | 0.319 | ||||
| Sanders et al. (12) | 1870 | 2002 | 0.96 | 1.264 | 0.206 | ||||
| Meta-analysis | 2963 | 3132 | 1.20 | 2.023 | 0.043 | 0.838 | |||
| rs821577 | 230133680 | 11808 | Present study | 782 | 839 | 0.92 | 1.066 | 0.286 | |
| Sullivan et al. (13) | 738 | 733 | 0.94 | 1.254 | 0.210 | ||||
| Hennah et al. (7), Edinburgh | 328 | 315 | 0.80 | 0.373 | 0.709 | ||||
| Hennah et al. (7), Helsinki | 343 | 342 | 0.91 | 1.303 | 0.193 | ||||
| Hennah et al. (7), Aberdeen | 256 | 255 | 0.85 | 0.982 | 0.326 | ||||
| Hennah et al. (7), London | 348 | 351 | 0.82 | 0.556 | 0.578 | ||||
| Meta-analysis | 2795 | 2835 | 1.23 | 2.285 | 0.022 | 0.988 |
In bold results with significant disease association across samples are presented (P-values association < 0.05, P-values heterogeneity > 0.05) using the weighted Z-score method (Comprehensive Meta Analysis v. 2)
aSNP marker positions according to NCBI Build 36.