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. 2007 Mar 14;27(11):2999–3009. doi: 10.1523/JNEUROSCI.4913-06.2007

Figure 1.

Figure 1.

STEP is expressed in GABAergic hilar interneurons. A, DAB-based immunohistochemical labeling revealed marked STEP expression in the hilus (Hil). Note the lack of STEP staining in the GCL. The boxed region is magnified and shown on the right. B, Top row, Immunofluorescent double labeling for STEP and GAD65/67 revealed that STEP is expressed in GABAergic hilar interneurons. Bottom row, STEP is also expressed in GAD65/67-positive neurons in the stratum oriens of CA1. Arrows indicate cells expressing STEP but not GAD65/67. C, Double labeling shows that somatostatinergic interneurons express STEP in the hilus (top row) as well as in the stratum oriens of CA1 (bottom row). Arrow denotes a somatostatin-negative cell weakly expressing STEP. Scale bars: A, 100 μm (low-magnification image) and 25 μm (high-magnification image); B, C, 20 μm. SO, Stratum oriens; PCL, pyramidal cell layer.