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The T1 effects on slice localization are suppressed by calculating the difference between profiles generated with opposite symmetry as shown for the (+--+) - (-++-) = 2(+--+) profile (a). Application of the Hadamard transform to the corrected profiles yields the slice selection profiles (b). The signal from the lactate methyne resonance is largely suppressed due the antiphase components of the multiplet as shown for slice 3 in the inset.
