Fig. 6.

Inhibition of pancreatic xenograft tumor growth in nude mice after treatment with indolequinones. MIA PaCa-2 xenograft tumors were grown on the flanks of nude mice and then treated with selected indolequinones (1.0 and 2.5 mg/kg i.p.) every other day for 20 days. Mice were weighed twice weekly, and neither the control mice nor the treatment groups suffered significant weight loss or any apparent toxicity. Tumor volume was calculated by the formula (L × W²)/2, where L is the longer measurement of the tumor and W is the smaller tumor measurement. Data represents the mean ± S.E.M. of six mice. ^*, tumor volume in the treatment group was statistically different from controls as determined by the Dunnett's test.