Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A proposed mechanism for the inhibition of TrxR by indolequinones. A, indolequinone activation by two-electron reduction to generate a reactive iminium electrophile. B, reduction of oxidized TrxR by NADPH to generate the reduced C-terminal selenocysteine. C, inhibition of TrxR via alkylation of the reduced C-terminal selenocysteine by the reactive indolequinone iminium electrophile.
