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. Author manuscript; available in PMC: 2009 Jun 24.
Published in final edited form as: J Steroid Biochem Mol Biol. 2007 Jun 27;107(3-5):131–139. doi: 10.1016/j.jsbmb.2007.05.031

FIGURE 4. COBRA1 does not affect the ligand sensitivity of AR-mediated transcriptional activation.

FIGURE 4

The control and COBRA1 knockdown cells were transfected with the MMTV-luciferase reporter plasmid, and subsequently treated with a serial 10-fold dilution of DHT, ranging from 10-11 M to 10-8 M. Transfected cells were also treated with AR antagonist flutamide (10-6 M) in the presence of 10-9 M DHT to ascertain the androgen-dependency of the observed luciferase expression.