Table II.
| Table II A. List of Genes Demonstrating Significant DE within the Cell Cycle Pathway | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | AffyID | Fold-Change | p-value |
| Up-regulated genes (expression higher post-vaccination than pre-vaccination) | ||||
| RRM2 | ribonucleotide reductase M2 polypeptide | 209773_s_at | 2.06 | 0.000002 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 204127_at | 1.78 | 0.000022 |
| PMS2 /// PMS2CL | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 209805_at | 1.93 | 0.000257 |
| PRC1 | protein regulator of cytokinesis 1 | 218009_s_at | 1.92 | 0.000321 |
| CCNB2 | cyclin B2 | 202705_at | 1.66 | 0.000377 |
| CCND2 | cyclin D2 | 200953_s_at | 1.42 | 0.000378 |
| GINS2 | DNA replication complex GINS protein PSF2 | 221521_s_at | 3.50 | 0.000599 |
| BUB1 | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 209642_at | 2.16 | 0.000754 |
| Down-regulated genes (expression lower post-vaccination than pre-vaccination) | ||||
| TSC1 | tuberous sclerosis 1 | 209390_at | −1.36 | 0.000023 |
| LCK | lymphocyte-specific protein tyrosine kinase | 204891_s_at | −1.31 | 0.000244 |
| CDC25B | cell division cycle 25B | 201853_s_at | −1.36 | 0.000428 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 203055_s_at | −1.36 | 0.000724 |
| Table II B. List of Genes Demonstrating Significant DE within the Cytokine Pathway | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | AffyID | Fold-Change | p-value |
| Up-regulated genes (expression higher post-vaccination than pre-vaccination) | ||||
| IFNG | interferon, gamma | 210354_at | 2.57 | 0.000022 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 210163_at | 2.39 | 0.000086 |
| IL6 | interleukin 6 (interferon, beta 2) | 205207_at | 2.18 | 0.000295 |
| IL3 | interleukin 3 (colony-stimulating factor, multiple) | 207906_at | 4.03 | 0.000303 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 203915_at | 1.91 | 0.000507 |
| TNF | tumor necrosis factor (TNF superfamily, member 2) | 207113_s_at | 1.81 | 0.000638 |
| IL15 | interleukin 15 | 205992_s_at | 1.32 | 0.000979 |
| Down-regulated genes (expression lower post-vaccination than pre-vaccination) | ||||
| GRN | granulin | 211284_s_at | −1.52 | 0.000082 |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | 203591_s_at | −1.44 | 0.000355 |
| Table II C. List of Genes Demonstrating Significant DE within the Defense Pathway | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | AffyID | Fold-Change | p-value |
| Up-regulated genes (expression higher post-vaccination than pre-vaccination) | ||||
| CTSC | cathepsin C | 201487_at | 1.52 | 0.000006 |
| IFNG | interferon, gamma | 210354_at | 2.57 | 0.000022 |
| INDO | indoleamine-pyrrole 2,3 dioxygenase | 210029_at | 2.47 | 0.000058 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 210163_at | 2.39 | 0.000086 |
| KIR2DS5 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 | 208203_x_at | 2.11 | 0.000110 |
| ADAR | adenosine deaminase, RNA-specific | 201786_s_at | 1.37 | 0.000249 |
| IL6 | interleukin 6 (interferon, beta 2) | 205207_at | 2.18 | 0.000295 |
| IL3 | interleukin 3 (colony-stimulating factor, multiple) | 207906_at | 4.03 | 0.000303 |
| AICDA | activation-induced cytidine deaminase | 219841_at | 2.91 | 0.000333 |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 206181_at | 1.42 | 0.000468 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 203915_at | 1.91 | 0.000507 |
| TNF | tumor necrosis factor (TNF superfamily, member 2) | 207113_s_at | 1.81 | 0.000638 |
| GZMA | granzyme A (granzyme 1, CTL-associated serine esterase 3) | 205488_at | 1.59 | 0.000755 |
| C1QB | complement component 1, q subcomponent, beta polypeptide | 202953_at | 1.59 | 0.000775 |
| IL15 | interleukin 15 | 205992_s_at | 1.32 | 0.000979 |
| Down-regulated genes (expression lower post-vaccination than pre-vaccination) | ||||
| CD14 | CD14 antigen | 201743_at | −2.46 | 0.000031 |
| ADORA2B | adenosine A2b receptor | 205891_at | −1.69 | 0.000077 |
| DPP4 | dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) | 203717_at | −1.35 | 0.000241 |
| LY86 | lymphocyte antigen 86 | 205859_at | −1.45 | 0.000340 |
| CSF3R | colony stimulating factor 3 receptor (granulocyte) | 203591_s_at | −1.44 | 0.000355 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 60528_at | −1.34 | 0.000546 |
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha | 218831_s_at | −1.68 | 0.000678 |
| Table II D. List of Genes Demonstrating Significant DE within the Inflammation Pathway | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | AffyID | Fold-Change | p-value |
| Up-regulated genes (expression higher post-vaccination than pre-vaccination) | ||||
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 210163_at | 2.39 | 0.000086 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 203915_at | 1.91 | 0.000507 |
| TNF | tumor necrosis factor (TNF superfamily, member 2) | 207113_s_at | 1.81 | 0.000638 |
| Down-regulated genes (expression lower post-vaccination than pre-vaccination) | ||||
| CD14 | CD14 antigen | 201743_at | −2.46 | 0.000031 |
| LY86 | lymphocyte antigen 86 | 205859_at | −1.45 | 0.000340 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 60528_at | −1.34 | 0.000546 |
| Table 2E. List of Genes Demonstrating Significant DE within the Interferon Pathway | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | AffyID | Fold-Change | p-value |
| Up-regulated genes (expression higher post-vaccination than pre-vaccination) | ||||
| INDO | indoleamine-pyrrole 2,3 dioxygenase | 210029_at | 2.47 | 0.0000584 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 203915_at | 1.91 | 0.0005074 |
*
(VLP-Media) expression levels as defined in the Materials and Methods Section