Keratitis frequency in B10-background mice. Bar graphs indicate percentage of mice in each category that had developed keratitis by 18–19 weeks of age, except for Group 4, in which mice were instead assessed for keratitis slightly earlier, at 15–16 weeks of age, due to the death of several mice. The actual number of mice with keratitis is indicated as a fraction of the total number examined for each category, shown next to each bar. (Note: in Group 4, one cyclosporin A-treated mouse developed keratitis early on but was clear of discernible disease after several weeks of Cyclosporin A treatment. This mouse was still counted as keratitic.) *Compared to B10.TCRδ−/− male historical controls, of which 5/35 were keratitic. ^Compared to B10.TCRδ−/− female historical controls, of which 29/36 were keratitic.