Fig. 2.

Comparison of the effects of all five drugs investigated on thrombin- induced [³H] arachidonate liberation in platelets. Gel-filtered, [³H] AA-labeled platelets were incubated with 0.25 U/ml of thrombin at 37°C in the absence (black bars) or presence of drugs (gray bars). After 90 s, the samples were extracted and processed as described in the “Materials and methods” section. The free [³H] AA produced is presented as percentage of a control containing no thrombin or drugs (set to 100%). The experiment was repeated three times, each time with platelets from a different donor (giving a sum of three experiments). The error bars show SEM, and the asterisks denote p < 0.05 compared to controls (i.e., without drugs)