Table 3.

Spectrum of anesthetic effects in deletion heterozygotes that show an altered sensitivity to halothane.

Strain/Genotype	Enflurane	Isoflurane	Sevoflurane
+/ED4065	−27.0% (−20.1 to −34.2)	−28.7% (−22.7 to −35.3)	−20.3% (−16.0 to −24.9)
+/ED5495	−13.2% (−7.8 to −19.7)	−13.1% (−9.5 to −16.9)	−22.1% (−18.0 to −26.6)
+/ED2247	−14.7 (−9.1 to −21.7)	+0.3% (−4.7 to +6.0)	+0.7% (−2.9 to +4.7)
+/ED2308	−10.1% (−5.1 to −15.3)	−1.7% (−4.3 to +0.9)	−7.0% (−3.6 to −10.4)
+/ED1725	+2.9% (−2.2 to +8.5)	+2.7% (0.0 to +5.6)	0.0% (−3.8 to +3.6)
+/ED1715	+1.3% (−3.8 to + 6.8)	+2.4% (−0.3 to +5.3)	−3.2% (−6.7 to +0.4)
+/ED1	−2.8% (−7.7 to +2.2)	+1.0% (−1.6 to +3.7)	−0.9% (−4.5 to +2.9)
+/ED2751	−14.4% (−9.2 to −20.0)	+1.0% (−1.6 to +3.7)	−2.6% (−6.1 to +1.0)

The strains described in Table 1 were tested for sensitivity of the righting/climbing reflex to enflurane, isoflurane and sevoflurane. The protocol for testing was exactly as described in Materials and Methods for construction of concentration-response curves for halothane except that the following sets of concentrations were used. For enflurane: 0.10%, 0.20%, 0.30%, and 0.35% plus 0.40%, 0.50%, 0.60%, and 0.70%. For isoflurane: 0.10%, 0.20%, 0.30%, 0.40%, and 0.43% plus 0.45%, 0.48%, 0.50%, and 0.60%. For sevoflurane: 0.10%, 0.30%, 0.50%, 0.60% and 0.75% plus 0.65%, 0.70%, 0.78%, and 0.90%. For each of these agents the % change in potency from the control heterozygote and the 95% confidence limits on this value, calculated as in Table 1, is given.