Table 3.

Classification of gene clusters based on serial alteration of gene expression along with the fibrosis progression

F1-F2	F2-F3	F3-F4
Inflammation
Wound-healing (ECM)
Blood coagulation
Transcription factors (cluster 1)	Transcription factors (cluster 2)
	Insulin/Wnt signal
Lipid metabolism
Steroid metabolism (cluster 1)	Steroid metabolism (cluster 1)
	Bile acid metabolism
Energy source AA metabolism (cluster 1)	Energy source AA metabolism (cluster 1)
	Aromatic AA metabolism
	Sulfur-containing AA metabolism
	Glucose metabolism (cluster 1)	Glucose metabolism (cluster 2)

Gene clusters are indicated under the name of gene category. The pattern of serial alteration for gene cluster was determined based on the maximum changing point of the expression ratio shown in Table 1.