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. 2009 Jul 14;7(7):e1000151. doi: 10.1371/journal.pbio.1000151

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Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Possible deformation pathways related to gating of ASIC1. Monomer is shown in cartoon representation with subdomains colored in green (thumb), magenta (finger), cyan (palm), orange (knuckle), blue (β turn), and red (TM). Three classes of movements within EC domain have been identified by NMA calculations: class I (consistent motions of thumb with finger, cyan arrows), class II (vibrations between finger and knuckle, black arrows), and class III (bending and twisting motions of the M-plane, red arrows). These motions are conducted to the TM domain through the M-plane and the consistent motions between β turn and TM. The green arrow indicates the twisting motions within TM domain. (B) The RMSF profiles for ASIC1 as a homotrimer (black line) versus its individual state (red line). ASIC1 subdomains are denoted at the top and correspond to the residue numbers listed along the horizontal axis.