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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Clin Immunol. 2009 Jan 25;131(2):260–270. doi: 10.1016/j.clim.2008.12.001

Figure 7. Tolerogenic effect of GM-CSF on DCs alone is sufficient to induce Foxp3+ T cells and suppress T1D.

Figure 7

A) DCs from female NOD scid mice treated with GM-CSF for 5 consecutive days or left untreated (naïve) were isolated and transferred i.v. into 7-week-old NOD mice (n=5/group) and the recipient mice were monitored weekly for blood glucose levels. B) Two weeks post-DC transfer, mice from a parallel experiment (n=3/group) were sacrificed and analyzed for Foxp3+ expression in both spleen and pancreatic lymph node (PLN) cells. Shown are percentage ranges of CD4+Foxp3+ T cells from 3 mice analyzed individually. Bars in the right panel represent mean ±SD of percentage of Foxp3+ T cells among CD4+ cells. ** represents p < 0.01.