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Organosulfur compounds in garlic. Garlic compounds such as Alliin, Allicin, S-allylcysteine (SAC), S-allyl mercaptocysteine (SAMC), diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) are metabolized to allyl mercaptan (AM), allyl methyl sulfide, and methyl mercaptan. AM was identified as a competitive HDAC inhibitor (Ki = 24 µM with human HDAC8) and induced histone acetylation in colon cancer cells [Nian et al., 2008].
