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. Author manuscript; available in PMC: 2009 Jun 25.
Published in final edited form as: Mol Pharmacol. 2008 Jun 10;74(3):614–627. doi: 10.1124/mol.108.048520

Figure 12. Steroid 3deoxy5αP potentiates the wild-type but not the α1Q241L mutant receptor.

Figure 12

(A) Structure of the steroid analogue 3deoxy5αP. (B) Comparison of potentiation of the wild-type receptor and the α1Q241L mutant receptor by 1 μM 3deoxy5αP. The data show mean ± SEM from 5-7 cells. (C) Sample macroscopic recordings from a cell expressing wild-type receptors. The receptors were activated by 5 μM GABA in the absence and presence of 1 μM 3deoxy5αP. The peak responses in this cell were 114 pA (GABA), and 281 pA (GABA + 3deoxy5αP). (D) Sample macroscopic recordings from a cell expressing α1Q241L mutant receptors. The receptors were activated by 20 μM GABA in the absence and presence of 1 μM 3deoxy5αP. The peak responses in this cell were 317 pA (GABA), and 305 pA (GABA + 3deoxy5αP).