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. Author manuscript; available in PMC: 2009 Jun 25.
Published in final edited form as: Mol Pharmacol. 2008 Jun 10;74(3):614–627. doi: 10.1124/mol.108.048520

Figure 3. Single-channel activity from the α1Q241W mutant receptor.

Figure 3

Each section shows three consecutive 10 s segments at a specific concentration of GABA. Channel openings are shown as downward deflections. (A) Channel activation by 2 μM GABA resulted in isolated openings and brief (<0.5 s) bursts of openings. No clusters were evident. (B) Channel activation by 10 μM GABA resulted in high open probability clusters of activity (shown with lines underneath the current traces). In addition to the clusters, the record contained brief bursts of activity and isolated openings of unknown origin, which were not included in the kinetic analysis. (C) Channel activation by 50 μM GABA resulted in clusters of activity and isolated openings. The clusters were defined as long-lived (>0.5 s) groups of activity separated from each other by periods of inactivity, ignoring isolated openings, greater than 1 s.