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. Author manuscript; available in PMC: 2009 Jun 25.
Published in final edited form as: Circulation. 2007 Jun 11;115(25):3197–3204. doi: 10.1161/CIRCULATIONAHA.106.657981

Figure 1. E2 inhibits the progression of heart failure in Gq transgenic mice.

Figure 1

A, Representative photomicrographs of hearts from FVB and Gq mice at 8 weeks after placebo or E2 pellet implantation (top; bar=2 mm). Elastica-van Gieson stain of myocardial cross sections (middle; bar=100 µm). Wheat-germ agglutinin staining of myocardial cross sections (bottom; bar=100 µm). B, RNA dot blot analysis of cardiac gene fetal expression. BNP indicates brain natriuretic factor; MLC-2v, myosin light chain-2 ventricular isoform; and α-SK, α-skeletal actin. Quantitative analysis of expression of each gene was normalized to GAPDH expression (n=8 in each group). Results are presented as mean±SD. *P<0.05 compared with placebo-treated FVB mice. †P<0.05 compared with placebo-treated Gq mice.