A, Trx1, TrxRD1, Trx2, and TrxRD2 mRNA expression levels in FVB and Gq mice at 8 weeks after placebo or E2 pellet implantation, analyzed by Northern blot. Expression levels of each mRNA were relative to those of GAPDH mRNA (n=9 in each group). Results are presented as mean±SD. *P<0.05 compared with placebo-treated FVB mice. †P<0.05 compared with placebo-treated Gq mice. B, TrxRD activity in mitochondrial and cytosolic fraction samples of hearts of FVB and Gq mice at 8 weeks after placebo or E2 pellet implantation (n=10 in each group). Results are presented as mean±SD. *P<0.05 compared with placebo-treated FVB mice. †P<0.05 compared with placebo-treated Gq mice.