Figure 3. In vivo selection in SIV-transduced animal RQ4513 after 2 cycles of BG/TMZ and 2 cycles of BG/BCNU.

Rhesus competitive repopulation experiments were set up using equal numbers of mobilized PB CD34⁺ cells transduced with SIV vectors expressing MGMT*-YFP or MGMT*-HOXB4-GFP. (A) Percent GFP⁺ and YFP⁺ granulocytes from PB. (B) Absolute number of YFP⁺ granulocytes. (C) Percent GFP⁺ and YFP⁺ monocytes from PB. (D) Percent GFP⁺ and YFP⁺ B cells and T cells from PB. Arrows denote cycles of drug administration; “†” indicates time of animal death.