Figure 5. In vivo selection in SIV-transduced animal RQ4152 after multiple cycles of BG/TMZ and 1 cycle of BG/BCNU.

Rhesus competitive repopulation experiments were set up using equal numbers of mobilized PB CD34⁺ cells transduced with SIV vectors expressing MGMT*-GFP or MGMT*-HOXB4-GFP. (A) Percent GFP⁺ granulocytes, B cells, T cells, and monocytes from PB for RQ4152. (B) Absolute number of GFP⁺ granulocytes. Arrows denote cycles of drug administration.