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. 2009 Jun 8;119(7):1997–2008. doi: 10.1172/JCI38519

Figure 7. Haploinsufficiency of Ext1 and Tgfb2 leads to aberrant iridocorneal development.

Figure 7

(A) There were no major anomalies noted in Schlemm canal (black arrows) or the trabecular beam (white arrowheads) for either the controls (A) or the Ext1 (B) or Tgfb2 (C) haploinsufficient mutants. As compared with the wild-type mice, the double heterozygote mice (D) had a hypoplastic trabecular beam, and they lacked a Schlemm canal. The double heterozygote mice also exhibited a significant reduction of the total cell number for the iridocorneal angle (E), in addition to an elevated IOP (F). Data represent mean ± SEM. *P < 0.01, Student’s t test (n = 9). Scale bar: 50 μm.