Skip to main content
. 2009 Jun 15;119(7):1871–1879. doi: 10.1172/JCI38575

Figure 1. pS1Pless mice exhibit basal vascular leak and increased local response to leak-inducing agents.

Figure 1

(A) Basal leak. Evans blue (1 mg/100 μl saline) was injected i.v., and 30 minutes later, mice were perfused with saline via the right ventricle, lungs were removed and photographed, and Evans blue content was determined. Left: Representative control and pS1Pless lungs. Right: Evans blue quantitation. Each point represents data for a separate mouse. The horizontal bars denote the mean. (B) Induced paw edema. Histamine (60 μg) or serotonin (20 μg) were injected into the hindpaws of pS1Pless mice and their control littermates. The contralateral paw was injected with vehicle. (Agent-injected paw thickness) / (vehicle-injected paw thickness) was determined at the indicated times and expressed as percent increase. Data are mean ± SEM. Note that responses to leak-inducing agents were higher in pS1Pless mice.