Table 1.

The Lyp inhibitory activities of compound 8a-8s and 11

Comp	R	R'	n	X	Y	IC50(μM)a
8a	H	CH3	1	O	S	21.0
8b	CH3	CH3	2	O	O	44.0
8c	CH3	CH3	2	S	O	>44
8d	CH3	CH3	1	S	O	>44
8e	H	H	1	O	S	8.7
8f	H	H	2	O	O	5.1
8g	H	H	2	S	O	5.9
8h	H	H	1	S	O	2.8
8i	H	H	1	S	S	5.4
8j	H	CH3	1	S	S	4.3
8k	CH3	CH3	1	O	O	>44
8l	H	CH3	1	S	O	18
8m	H	CH3	1	O	O	>44
8n	H	H	1	O	O	5.6
8o	H	CH3	2	O	O	4.3
8p	H	CH3	2	S	O	0.39
8q	CH3	H	1	O	O	4.8
8r	CH3	H	1	S	O	1.8
8s		H	0	O	S	1.4
11						>44

^aIC₅₀ values are determined from a single experiment performed in triplicate