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The inhibitory activities of the Schiff base analogs
 | ||||
|---|---|---|---|---|
| Comp | R | R' | X | IC50(μM)a |
| 12a | H | CH3 | O | >44 |
| 12b | H | H | O | >44 |
| 12c | H | CH3 | S | >44 |
| 12d | H | H | S | 34.0 |
| 17a | CH2CO2H | H | O | 36.0 |
| 17b | CH2CO2H | H | S | >44 |
IC50 values are determined from a single experiment performed in triplicate
