Figure 1.

Airway hyperresponsiveness in C57BL/6 wild-type and NAD(P)H quinone oxidoreductase 1 (NQO1)-null mice after filtered air (FA) or ozone (OZ) exposure. Twenty-four hours after OZ or FA exposure, mice were anesthetized for invasive measures of total pulmonary resistance in response to methacholine by impulse oscillometry with the flexivent ventilator (n = 5 animals/group; mean ± SEM; *significantly different from corresponding air control, P < 0.05; ^#significantly different from WT-ozone exposed animals, P < 0.05).