Figure 1.

Small proline-rich (Sprr) family proteins are highly up-regulated in fibroblasts by the addition of carbon monoxide (CO) to transforming growth factor (TGF)-β₁ stimulation. (A) The scatter plot shows Sprr family genes highlighted in red (Sprr1a is shown in green). The relative expression of Sprr1a, Sprr2a, and Sprr3 mRNA in response to TGF-β₁ treatment and TGF-β₁ plus CO treatment are shown by microarray analysis (B) and real-time PCR (C). (D) Expression of heat shock factor 4 (HSF4) mRNA in response to TGF-β₁ treatment assessed by microarray analysis and real-time PCR.