TABLE 1.

FOUR HIGHEST-SCORING CATEGORIES OF GENES GROUPED ACCORDING TO BIOLOGICAL FUNCTION

Functional Category	Range P Values	Log P Value	Genes
Ubiquitin proteasome pathway	1 × 10−4 to 2 × 10−2	−4.0	AMFR, BIRCH4, PSMB3, PSMB5, PSMB8, PSMD1, PSMD3, PSMD8, PSMD14, SMURF1, TCEB1, UBD, UBE2A, UBE2J2, USP1, USP5, USP26, USP38, USP9X, VDP, VHL
Skeletal and muscular system development and function	1 × 10−4 to 4 × 10−2	−3.8	MMP9, MMP13, SMURF1, ANKH, MEOX1, PHC1, RPS6KA3, TP73L, SOX2, FHL2, ACTA2, TNNT2, TNNT3, TMOD4, WNT10B, EGR1, PLAUR, HSF4, PDLIM7, SPNB2, DACH2, RRAS2, USMG1, MTM1, TAGLN, ACTG2
Cell movement	2 × 10−4 to 4 × 10−2	−3.7	PLAUR, TAGLN, CD97, MMP9, CRK, EGR1, ANGPTL4, APBB2, BDNF, CXCL13, DUSP1, FHL2, NEDD9, PENK, PPBP, SERPINA3, SEMA3C, ZYX, SH2D2A, CXCR6, PRKD1, TP73L, ALOX5AP
Cell death	2 × 10−4 to 4 × 10−2	−3.6	MMP9, MMP13, BDNF, PPBP, PLAUR, TUB, RUNX3, ATP1A1, MME, HSPA1B, EGR1, WWOX, TRP63, STC2, AKT3, POLB, TLR3, HDAC2