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. Author manuscript; available in PMC: 2009 Jun 25.
Published in final edited form as: J Theor Biol. 2007 Feb 6;246(4):755–761. doi: 10.1016/j.jtbi.2007.01.022

Fig.3. Responses of netwrok motifs to stimulation.

Fig.3

A. Response of the positive feedforward motif to a stimulation pulse. B. Response of the positive feedforward motif (Fig.2A) to multiple stimulation pulses. C. Response of the positive feedback motif (Fig.2B) to a stimulation pulse. D. Steady state response R to the strength of a constant stinulus S for the positive feedback motif, showing bistablity and an irreversible steady state. E. Steady state response to the strength of a constant stimulus S for the positive feedback motif and for a module composed of a positive feedback motif and a negatvie feedback motif, showing the conversion of an irreversible response to a reversible one following addition of a negative feedback motif. In D and E, dashed lines are unstable steady states. The gray areas are negative stimulation strengths which cannot exist in a real system, thereby manifesting as irreversible responses.