Table 2.

New diagnostic criteria for hepatorenal syndrome in cirrhosis[146]

Cirrhosis with ascites

Serum creatinine > 133 μmol/L (1.5 mg/dL)

No improvement of serum creatinine level (decrease to ≤ 133 μmol/L) after at least 2 d with diuretic withdrawal and volume expansion with albumin. The recommended dose of albumin is 1 g/kg of body weight per day up to a maximum of 100 g/d

Absence of shock

No current or recent treatment with nephrotoxic drugs

Absence of parenchymal kidney disease as indicated by proteinuria > 500 mg/d, microhematuria (> 50 red blood cells per high-power field) and/or abnormal renal ultrasonography