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. Author manuscript; available in PMC: 2009 Nov 18.
Published in final edited form as: Biochemistry. 2008 Oct 23;47(46):12028–12036. doi: 10.1021/bi801473w

Figure 2.

Figure 2

The active site of site-specific mutants (A) N62A, (B) N62V, (C) N62T, and (D) N62D HCA II. Residues are labeled and shown as stick models; the zinc atom is depicted as a white sphere and the oxygens of solvent water molecules as red spheres. Note the side chain of His64 is orientated inward for N62A and N62V, both inward and outward for N62T, and outward for N62D HCA II. The Fo-Fc electron density map was generated by omitting the residues at position 62, 64, and five water molecules in the active site. The map is depicted as a blue mesh and contoured at 3 σ for each site-specific mutant. This figure was generated and rendered with PyMOL (www.pymol.org).