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. Author manuscript; available in PMC: 2009 Dec 11.
Published in final edited form as: Nature. 2009 Jun 11;459(7248):802–807. doi: 10.1038/nature08085

Figure 4. Histone H4K16 and H3K56 mutations affect replicative lifespan through distinct mechanisms.

Figure 4

(a-b) Replicative lifespan analysis (MLS in parenthesis) (a) and ChIP analysis with histone H4 antibody (b) for cells bearing WT histone H4, H4K16R, or H4K16Q plasmids. Fold changes for H4K16Q compared to H4WT in ChIP analysis are indicated above the bars. Error bars show standard deviations (n=3). (c-d) Replicative lifespan analysis for strains carrying WT histone H3, H3K56R, or H3K56Q plasmids (c) and strains WT, rtt109Δ (d) with MLS in parenthesis. Lifespan p-values are listed in Supplementary Table 5.