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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: J Immunol. 2009 May 15;182(10):5904–5908. doi: 10.4049/jimmunol.0900732

Figure 4.

Figure 4

IL-23R expression on APCs is dispensable for the development of EAE. A, Single cell suspensions were prepared from Lymph nodes (LNs) from naive either RAG2 -/- or IL-23R-GFP.KI RAG2 -/- mice and IL-23R(GFP) expression was analyzed on total LNs' cells. B, IL-23R-GFP.KI mice were immunized with MOG35-55/CFA. On day 17, IL-23R(GFP) expression was analyzed on myeloid cell populations as indicated in histogram. C, MOG specific TH17 cells were i.v transferred into RAG2-/- and RAG2-/-IL-23R-/- mice. The course of EAE in these mice were monitored and shown as mean clinical score. D, Naïve T cells derived from MOG specific mice were i.v transferred into RAG2-/- or IL-23R-/- RAG2-/- mice. 24 h later, the mice were immunized with MOG35-55 emulsified in CFA. The course of EAE in these mice were monitored and shown as mean clinical score.