Plasma cholesterol (Fig 1A) and triglycerides (Fig 1B) in LDLr−/− mice fed a western-type diet, with (open bars) or without (closed bars) TZ, for 12 weeks. No significant difference between the groups. Values are means ± SEM. Female controls (n = 14), TZ (n = 15); Male controls (n = 13), TZ (n = 15). Size distribution of lipoprotein particles in female (Fig 1C) and male (Fig 1D) mice after 12 weeks (closed squares/circles, control mice; open squares/circles, TZ treated mice). Plasma was pooled from 4 or 5 mice in each treatment group (3 pools per group) and fractionated by FPLC. Cholesterol content was determined in each fraction. FPLC data shown represents the average cholesterol in each fraction, weighted for the number of mice in each pool.