Body weight increase and WAT size in LDLr−/− mice fed a western-type diet, with (open bars) or without (closed bars) TZ, for 12 weeks. A) Percentage increase in body weight from baseline to 12 weeks. B, C, D) After 12 weeks, the weights of their abdominal, retro-peritoneal and inguinal white adipose tissue depots were calculated as a percentage of their total body weights. Values are means ± SEM. Female controls (n = 14), TZ (n = 15); Male controls (n = 13), TZ (n = 15).