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Different HO-1 expression levels are associated with variable susceptibility to chemotherapy. Cell viability was assessed 72 h after application of gemcitabine via MTT assay. Both cell lines showed dose dependent growth inhibition under treatment with gemcitabine. S2-013 cell line with low native HO-1 expression was significantly more susceptible to gemcitabine (LD50 [S2-013] ~2.13 ng/ml) than PANC-1 cell line with high native HO-1 expression (LD50 [PANC-1] ~7.53 ng/ml).
