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. 2009 Jun 9;8:37. doi: 10.1186/1476-4598-8-37

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Copyright © 2009 Nuhn et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inhibition of HO-1 activity leads to increased susceptibility to chemotherapy in vitro. Cell viability was assessed 72 h after application of gemcitabine via MTT assay. (3A) Under gemcitabine treatment (LD50 dose) application of ZnPP revealed a dose dependent growth inhibition of PANC-1 cancer cells, whereas application of CoPP had no significant effect on cell proliferation. (3B) In S2-013 cell line implementation of CoPP led to increased cell proliferation, whereas ZnPP had no significant effect.