Figure 4.

Inhibition of HO-1 activity leads to increased susceptibility to chemotherapy of solid tumor growth. Primary pancreatic tumor weights were assessed 4 and 8 weeks after orthotopic tumor implantation of cancer cells in nude mice (n = 60, 15 per group). (4A) ZnPP treatment reduced tumor growth in gemcitabine treated mice after PANC-1 cancer cell implantation significantly, compared to gemcitabine treated tumors only. (4B) Administration of gemcitabine in combination with CoPP or ZnPP in mice implanted S2-013 cancer cells did not significantly change tumor weights in comparison to gemcitabine treatment alone. The use of ZnPP in combination with gemcitabine showed a trend towards lower tumor growth.