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Time to CDMS in mono- vs multifocal placebo patients stratified by MRI findings at screening. Note the predictive value of baseline MRI findings in monofocal patients (left panels) and the absence of predictive value of MRI in multifocal patients (right panels). There was a significant interaction between mono-/multifocality and the presence of either ≥ 9 T2 hyperintense lesions (p = 0.042). CDMS: clinically definite MS.
